Human Recombinant TGF-β1

Transforming Growth Factor Beta 1

Human recombinant protein from the MegaProt line, developed for signaling, differentiation, extracellular matrix, and advanced cellular model studies.

TGF-β1 MegaProt is currently in Beta validation stage. The technical information presented is referential and may be updated as characterization, stability, biological activity, and functional validation assays progress. For updated information regarding availability, format, and conditions of use, please contact us directly.

Beta Stage

Human Origin

Functional Studies

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Biological Source Human

Content
Expressed in a human Megakaryoblastic cell line
Format
Lyophilized
Molecular Weight
~14 kDa monomer / ~28 kDa dimer
Storage Conditions
Once reconstituted, aliquot and store at -80°C until use
Suggested Application
Cell culture
Storage Temperature
-20°C a -80°C

General Description

TGF-β1 is a multifunctional cytokine involved in the regulation of cellular processes such as proliferation, differentiation, apoptosis, and extracellular matrix production. Its effect depends on the cell type, concentration used, and experimental context, making it widely used in signaling and cellular behavior studies.

Biological Action

TGF-β1 can act as either a positive or negative regulator of cell growth depending on the experimental model. In certain contexts, it inhibits proliferation and induces apoptosis, while in others it participates in differentiation, extracellular matrix remodeling, and activation of cellular programs associated with repair, fibrosis, or tissue plasticity.

Usage Considerations

The use of TGF-β1 requires careful definition of cell type, culture status, concentration, exposure time, and the presence of other factors in the medium. Due to its pleiotropic nature, dose-response curves and specific marker evaluation are recommended according to the experimental objective.

WHAT IS IT USED FOR?

TGF-β1 recombinant human can be evaluated in studies aimed at modulating specific cellular responses, including differentiation, signaling, fibrosis, regeneration, and extracellular matrix production. Its application will depend on the cell model, the concentration used, and the objectives of each investigation.
Cell Signaling

Studies associated with TGF-β/SMAD pathways and regulation of cellular responses in defined experimental models.
Fibrosis and Extracellular Matrix

Evaluation of collagen production, tissue remodeling, and fibrogenic phenotypes in in vitro systems.
Cell Differentiation

Modulation of cellular states in epithelial, mesenchymal, stem cell, or organoid models.
In Vitro Models

Development of experimental systems to study plasticity, regeneration, and cellular behavior.

REQUEST YOUR SAMPLE

Tell us about your experimental model and we will guide you on availability, conditions of use, and evaluation of TGF-β1 MegaProt.

1

Contact Us

Complete the Beta sample request form.

2

Evaluation

We review your research profile and intended use.

3

Delivery

We ship the sample with an included usage protocol.

4

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